Ammonia → (2R,3S)-3-(4-methoxyphenyl)-2,3-epoxypropionamide
반응식
C[O:2][C:3](=O)[C@@H:4]1[O:6][C@H:5]1[C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][CH:8]=1.[NH3:16]>CN(C)C=O>[CH3:14][O:13][C:10]1[CH:11]=[CH:12][C:7]([C@@H:5]2[O:6][C@H:4]2[C:3]([NH2:16])=[O:2])=[CH:8][CH:9]=1참가 물질
4
실험 절차
To a mixture of (2R,3S)-3-(4-methoxyphenyl)-2,3-epoxypropionic acid methyl ester (2.08 g) and N,N-dimethylformamide (3 ml) is added 28% aqueous ammonia (6.1 g) under ice-cooling. The mixture is reacted at room temperature for two hours, and the precipitated crystals are collected by filtration, washed with water, and dried at 50° C. to give (2R,3S)-3-(4-methoxyphenyl)-2,3-epoxypropionamide (1.64 g).
후처리
- temperaturecooling
- customThe mixture is reacted at room temperature for two hours
- filtrationthe precipitated crystals are collected by filtration
- washwashed with water
- customdried at 50° C.
출처 및 근거
- ORD 기록
- ord-b348ca99a0de49b6abd77e4ed58521b4
- 출처 데이터셋
- uspto-grants-1998_12
- 특허 번호
- US05847122
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