Methylamine → (2S,3R)-3-(4-methylphenyl)-2,3-epoxy-N-methylpropionamide

HRID 1457259노트

반응식

HRID 1457259 반응식
C[O:2][C:3](=O)[C@H:4]1[O:6][C@@H:5]1[C:7]1[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=1.[CH3:15][NH2:16]>CO>[CH3:13][C:10]1[CH:11]=[CH:12][C:7]([C@H:5]2[O:6][C@@H:4]2[C:3]([NH:16][CH3:15])=[O:2])=[CH:8][CH:9]=1

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 10176494(2S,3R)-3-(4-methylphenyl)-2,3-epoxypropionic acid methyl ester

생성물 1

HCID 56977863(2S,3R)-3-(4-methylphenyl)-2,3-epoxy-N-methylpropionamide수율 91.6%

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

To a mixture of (2S,3R)-3-(4-methylphenyl)-2,3-epoxypropionic acid methyl ester (1.92 g) and methanol (10 ml) is added dropwise a solution of 40% aqueous methylamine solution (2.37 g) in methanol (10 ml) under ice-cooling. The reaction mixture is stirred under ice-cooling for one hour, and concentrated under reduced pressure. To the residue is added ether, and the precipitated crystals are collected by filtration, washed, and dried at 50° C. to give (2S,3R)-3-(4-methylphenyl)-2,3-epoxy-N-methylpropionamide (1.75 g).

후처리

  1. temperaturecooling
  2. temperaturecooling for one hour
  3. concentrationconcentrated under reduced pressure
  4. additionTo the residue is added ether
  5. filtrationthe precipitated crystals are collected by filtration
  6. washwashed
  7. customdried at 50° C.

출처 및 근거

ORD 기록
ord-9db6e93a58d04a99a57f88bbadf95848
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05847122

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