Water → HCID 23289956, 화합물

HRID 1457525노트

반응식

HRID 1457525 반응식
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Br[CH2:8][C:9]([C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[NH:16][C:15](=[O:20])[CH2:14]2)=[O:10].O>CN(C)C=O>[N:1]1([CH2:8][C:9]([C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15](=[O:20])[CH2:14]3)=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 962WaterHCID 8082PiperidineHCID 220993095-(Bromoacetyl)-1,3-dihydro-2H-indol-2-one

생성물 1

HCID 23289956HCID 23289956, 화합물수율 49.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of piperidine (0.39 ml, 3.9 mmole) and 5-(2-bromoacetyl)-2-indolinone (500 mg, 1.97 mmole) in N,N-dimethylformamide (15 ml) was stirred at room temperature 4 h then was poured into water (50 ml) and washed with dichloromethane (250 ml), the organic solution was washed with water several times and dried over sodium sulfate. After evaporation of the solvent the residue was chromatographed on siiica-gel using ethyl acetate as eluant to give 5-(2-piperidin-1-yl-acetyl)-2-indolinone (250 mg).

후처리

  1. washwashed with dichloromethane (250 ml)
  2. washthe organic solution was washed with water several times
  3. dry with materialdried over sodium sulfate
  4. customAfter evaporation of the solvent the residue
  5. customwas chromatographed on siiica-gel

출처 및 근거

ORD 기록
ord-2ec7ae9f58e54e2bb562f0ff5e9b9647
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05849710

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