Methyl isothiocyanate → 1,1-Dimethyl-4-methyl-2-(3-pyridylmethyl)thiosemicarbazide

HRID 1457897노트

반응식

HRID 1457897 반응식
[CH3:1][N:2]([CH3:11])[NH:3][CH2:4][C:5]1[CH:6]=[N:7][CH:8]=[CH:9][CH:10]=1.[CH3:12][N:13]=[C:14]=[S:15]>C1(C)C=CC=CC=1>[CH3:1][N:2]([CH3:11])[N:3]([CH2:4][C:5]1[CH:6]=[N:7][CH:8]=[CH:9][CH:10]=1)[C:14]([NH:13][CH3:12])=[S:15]

참가 물질

4

반응물 2

HCID 11167Methyl isothiocyanateHCID 111481501,1-Dimethyl-2-(3-pyridylmethyl)hydrazine

생성물 1

HCID 224505201,1-Dimethyl-4-methyl-2-(3-pyridylmethyl)thiosemicarbazide수율 70.6%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

In 30 ml of toluene was dissolved 2.5 g of 1,1-dimethyl-2-(3-pyridylmethyl)hydrazine followed by addition of 1.2 g of methyl isothiocyanate and the mixture was refluxed for 1 hour. The reaction mixture was concentrated and the resulting crystals are collected by filtration, washed with ethyl ether and dried. The procedure gave 2.6 g of 1,1-dimethyl-4-methyl-2-(3-pyridylmethyl)thiosemicarbazide as white prisms.

후처리

  1. temperaturethe mixture was refluxed for 1 hour
  2. concentrationThe reaction mixture was concentrated
  3. filtrationthe resulting crystals are collected by filtration
  4. washwashed with ethyl ether
  5. customdried

출처 및 근거

ORD 기록
ord-5b00f403d18c4934b1aefb915d93d9ed
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05849768

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