4,4-Diethoxybutylamine → HCID 70270548, 화합물

HRID 1458022

반응식

HRID 1458022 반응식
[CH2:1]([O:3][CH:4]([O:9][CH2:10][CH3:11])[CH2:5][CH2:6][CH2:7][NH2:8])[CH3:2].[S:12](Cl)([OH:15])(=O)=[O:13].[CH:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[CH2:10]([O:9][CH:4]([O:3][CH2:1][CH3:2])[CH2:5][CH2:6][CH2:7][NH:8][S:12]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)(=[O:15])=[O:13])[CH3:11]

참가 물질

3

반응물 2

HCID 806724,4-DiethoxybutylamineHCID 22564087Benzene sulphochloride

생성물 1

HCID 70270548HCID 70270548, 화합물수율 86%

실험 절차

42 g 4-amino butyraldehyde diethyl acetal and 88 g benzene sulfochloride are processed as explained in Preparation Example 1. The reaction mixture is not clear from the very beginning and vigorous stirring is therefore indispensable. Methylene chloride is used for the extraction of the sulfonamide acetal. Yield: 86% based on the amino acetal used. The product will crystallize when standing for an extended time at room temperature; melting point: 109°-111° C.; for further purification recrystallization from a 2:1 volume mixture of water and ethanol is possible.

후처리

  1. customas explained in Preparation Example 1
  2. extractionMethylene chloride is used for the extraction of the sulfonamide acetal
  3. customThe product will crystallize when
  4. customstanding for an extended time at room temperature
  5. customfor further purification recrystallization
  6. additionfrom a 2:1 volume mixture of water and ethanol

출처 및 근거

ORD 기록
ord-d9f122c8b3c4405781cfe5069be61f84
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05849842

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