2-Ethylazepane → HCID 59341131, 화합물

HRID 14582

반응식

Cl[C:2]1[C:7]([F:8])=[C:6]([Cl:9])[N:5]=[CH:4][N:3]=1.[CH2:10]([CH:12]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][NH:13]1)[CH3:11]>>[Cl:9][C:6]1[N:5]=[CH:4][N:3]=[C:2]([N:13]2[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH:12]2[CH2:10][CH3:11])[C:7]=1[F:8]

참가 물질

반응물 2

HCID 43359322-Ethylazepane

HCID 112866754,6-Dichloro-5-fluoropyrimidine

생성물 1

HCID 59341131HCID 59341131, 화합물수율 97.2%

실험 절차

0.4 g of 4,6-dichloro-5-fluoropyrimidine and 0.61 g of 2-ethylhexahydro-1H-azepine were mixed and left for 1 hour at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.6 g of 1-(6-chloro-5-fluoropyrimidin-4-yl)-2-ethylhexahydro-1H-azepine.

출처 및 근거

ORD 기록: ord-57b881efbb094cde83d75b964815a1a8
출처 데이터셋: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07732448B2

연결된 노트

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