Sodium Bicarbonate → 1-(4-Methyl-5-oxazolyl)-1-phenylmethanol
반응식
[CH3:1][C:2]1[N:3]=[CH:4][O:5][C:6]=1[CH:7]=[O:8].[C:9]1([Li])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C(=O)([O-])O.[Na+]>O1CCCC1>[CH3:1][C:2]1[N:3]=[CH:4][O:5][C:6]=1[CH:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[OH:8]참가 물질
5
실험 절차
4-Methyl-5-oxazolecarbaldehyde (600 mg) in dry tetrahydrofuran (10 ml) was added dropwise to a stirred solution of phenyllithium (2.0M solution in cyclohexane and diethyl ether, 2.8 ml) in tetrahydrofuran (20 ml) at -70° C. under an atmosphere of dry nitrogen. After 1 hour the mixture was allowed to warm to room temperature. After a further 1 hour saturated aqueous sodium hydrogen carbonate was added and the mixture was extracted with ethyl acetate. The product was purified by flash chromatography to yield the title compound. M.p. 79°-81° C.
후처리
- extractionthe mixture was extracted with ethyl acetate
- customThe product was purified by flash chromatography
출처 및 근거
- ORD 기록
- ord-e3f718e7d8ef4d708180674db2d2fed9
- 출처 데이터셋
- uspto-grants-1998_12
- 특허 번호
- US05849921
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