Ammonia → HCID 22101782, 화합물
반응식
[NH3:1].[Cl:2][C:3]1[C:4](F)=[N:5][C:6]([F:13])=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1>C(O)C>[NH2:1][C:4]1[C:3]([Cl:2])=[CH:8][C:7]([C:9]([F:12])([F:11])[F:10])=[C:6]([F:13])[N:5]=1참가 물질
4
반응 조건
- 온도
- 55 °C
실험 절차
12.5 g (0.74 mol) of gaseous ammonia were passed into a stirred mixture of 40 g (0.184 mol) of 3-chloro-2,6-difluoro-5-trifluoromethylpyridine in 200 ml of ethanol in the course of 45 minutes at 50°-60° C. After the reaction mixture had been stirred for 11/2 hours at 55° C., it was cooled and concentrated. The residue was stirred in water, filtered off with suction and dried, giving 36.7 g (93% of theory) of the title compound of m.p. 101°-103° C.
후처리
- temperatureit was cooled
- concentrationconcentrated
- stirringThe residue was stirred in water
- filtrationfiltered off with suction
- customdried
출처 및 근거
- ORD 기록
- ord-e4d2345060fc4ef08b372989df22edcd
- 출처 데이터셋
- uspto-grants-1998_12
- 특허 번호
- US05849920
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