Tetrabutylammonium Fluoride → 4-(3-Methylisoxazol-5-yl)butan-1-ol

HRID 1458352노트

반응식

HRID 1458352 반응식
[Si]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[O:17][N:16]=[C:15]([CH3:18])[CH:14]=1)(C(C)(C)C)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1>[CH3:18][C:15]1[CH:14]=[C:13]([CH2:12][CH2:11][CH2:10][CH2:9][OH:8])[O:17][N:16]=1

참가 물질

4

반응물 2

HCID 2724141Tetrabutylammonium FluorideHCID 221009045-[4-(Tert-butyldirnethylsilanyloxy)butyl]-3-methylisoxazole

생성물 1

HCID 221009164-(3-Methylisoxazol-5-yl)butan-1-ol수율 72.9%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 5-[4-(tert-butyldirnethylsilanyloxy)butyl]-3-methylisoxazole (350 mg in 5 mL dry tetrahydrofuran) at 0° C. was added 1.62 mL of a 1M solution of tetrabutylammonium fluoride in tetrahydrofuran and the mixture stirred while warming to room temperature. After 16 hours, the mixture was concentrated in vacuo and the residue purified by flash chromatography on silica gel (ethyl acetate:hexane, 1:3, then 1:1) to give the title compound (147 mg).

후처리

  1. concentrationthe mixture was concentrated in vacuo
  2. customthe residue purified by flash chromatography on silica gel (ethyl acetate

출처 및 근거

ORD 기록
ord-a5ce27bcc5534cc5b3eedb0f54a1e2cf
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05849764

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