Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 14584생성일: 2026년 10월 26일
rel-(2R,6S)-2,6-Dimethylpiperidine → 4-Chloro-6-(cis-2,6-dimethylpiperidino)-5-fluoropyrimidine
https://huagongshe.com/reaction/14584
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | rel-(2R,6S)-2,6-Dimethylpiperidine | HCID 641768 | — |
| 반응물 | 4,6-Dichloro-5-fluoropyrimidine | HCID 11286675 | — |
| 생성물 | 4-Chloro-6-(cis-2,6-dimethylpiperidino)-5-fluoropyrimidine | HCID 86607467 | 57.5% |
반응 단계
0.25 g of 4,6-dichloro-5-fluoropyrimidine and 0.34 g of cis-2,6-dimethylpiperidine were mixed and stirred for 11 hours at 70° C. The reaction mixture was subjected to silica gel column chromatography to obtain 0.21 g of 4-chloro-6-(cis-2,6-dimethylpiperidino)-5-fluoropyrimidine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07732448B2 |
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| 출처 데이터셋 | uspto-grants-2010_06 |
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| ORD ID | ord-0817df69e5fb453f85648bdb00310dde |
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| 출처 메모 | uspto-grants-2010_06 |
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