Hydrazine → Ethyl 2-hydrazinyl-4-methylpyrimidine-5-carboxylate

HRID 1458638노트

반응식

HRID 1458638 반응식
Cl[C:2]1[N:7]=[C:6]([CH3:8])[C:5]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:4][N:3]=1.[NH2:14][NH2:15]>C1COCC1>[NH:14]([C:2]1[N:7]=[C:6]([CH3:8])[C:5]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:4][N:3]=1)[NH2:15]

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 21220624Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate

생성물 1

HCID 12427976Ethyl 2-hydrazinyl-4-methylpyrimidine-5-carboxylate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The title compound was prepared as described in Example 18, but employing a solution of ethyl 2-chloro-4-methylpyrimidine-5-carboxylate (0.08 g, 0.39 mmol) and hydrazine (0.06 g, 2.0 mmol) in THF (7.8 mL) resulting in a 93% yielded (0.07 g); 1HNMR (CDCl3) δ 8.86 (s, 1H), 6.64 (bs, 1H), 4.33 (q, 2H), 2.70 (s, 3H), 1.38 (t, 3H).

후처리

  1. customresulting in a 93%
  2. customyielded (0.07 g)

출처 및 근거

ORD 기록
ord-ff706c92a6e24a4d8d87eee9640280f3
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05852028

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