Dehydrocavidine dehydroapocavidine → Dehydroisoapocavidine

HRID 14588

반응식

HRID 14588 반응식
[CH3:1][C:2]1[C:11]2[C:12]3[C:17]([CH2:18][CH2:19][N+:10]=2[CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]1[O:26][CH2:25][O:24][C:7]=12)=[CH:16][C:15]([O:20][CH3:21])=[C:14]([O:22][CH3:23])[CH:13]=3.[Cl-:27].[CH3:28][C:29]1[C:38]2[C:39]3[C:44]([CH2:45][CH2:46][N+:37]=2[CH:36]=[C:35]2[C:30]=1[CH:31]=[CH:32][C:33]1[O:52][CH2:51][O:50][C:34]=12)=[CH:43][C:42]([O:47][CH3:48])=[C:41]([OH:49])[CH:40]=3>CO>[CH3:1][C:2]1[C:11]2[C:12]3[C:17]([CH2:18][CH2:19][N+:10]=2[CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]1[O:26][CH2:25][O:24][C:7]=12)=[CH:16][C:15]([O:20][CH3:21])=[C:14]([O:22][CH3:23])[CH:13]=3.[Cl-:27].[CH3:28][C:29]1[C:38]2[C:39]3[C:44]([CH2:45][CH2:46][N+:37]=2[CH:36]=[C:35]2[C:30]=1[CH:31]=[CH:32][C:33]1[O:52][CH2:51][O:50][C:34]=12)=[CH:43][C:42]([O:47][CH3:48])=[C:41]([OH:49])[CH:40]=3

참가 물질

4

반응물 1

HCID 131728162Dehydrocavidine dehydroapocavidine

생성물 2

HCID 9974201DehydroisoapocavidineHCID 44559283Dehydrocavidine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

200 mg of the dehydrocavidine-dehydroapocavidine composition obtained from the above step is dissolved with 10 ml of methanol, and are then loaded to the top of the sephadex gel column, and a gradient elution is employed with 30%˜70% methanol, accompanied by TLC tracking. The eluate containing dehydrocavidine is combined and is then concentrated by decompression to a constant weight, resulting in obtaining 22 mg of a dehydrocavidine compound and 14 mg of a dehydroapocavidine compound respectively.

후처리

  1. washa gradient elution
  2. additionThe eluate containing dehydrocavidine
  3. concentrationis then concentrated by decompression to a constant weight
  4. customresulting

출처 및 근거

ORD 기록
ord-864196ae632e4aceaa2104297d6f9e87
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732458B2

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