1-Bromo-3,6-dioxaheptane → N-Benzyloxycarbonyl-3-[4-(1,4,7-trioxaoctyl)-phenyl]-alanine-tert-butyl ester

반응식

[C:1]([O:5][C:6](=[O:27])[C@H:7]([CH2:19][C:20]1[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][CH:21]=1)[NH:8][C:9]([O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:10])([CH3:4])([CH3:3])[CH3:2].Br[CH2:29][CH2:30][O:31][CH2:32][CH2:33][O:34][CH3:35]>>[C:1]([O:5][C:6](=[O:27])[C@H:7]([CH2:19][C:20]1[CH:21]=[CH:22][C:23]([O:26][CH2:29][CH2:30][O:31][CH2:32][CH2:33][O:34][CH3:35])=[CH:24][CH:25]=1)[NH:8][C:9]([O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:10])([CH3:4])([CH3:2])[CH3:3]

참가 물질

반응물 2

HCID 1235321-Bromo-3,6-dioxaheptane

HCID 11428694Z-Tyr-OtBu

생성물 1

HCID 22940771N-Benzyloxycarbonyl-3-[4-(1,4,7-trioxaoctyl)-phenyl]-alanine-tert-butyl ester

실험 절차

7.43 g (20 mmol) of N-benzyloxycarbonyl-tyrosine-tert-butyl ester is reacted with 1-bromo-2-(2-methoxyethoxy)ethane to alkylated phenol analogously to Example a).

출처 및 근거

ORD 기록: ord-fb039f92c05c4702bff1dc6c4260ca28
출처 데이터셋: uspto-grants-1998_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05853699

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