p-Toluenesulfonic acid monohydrate → 2-benzyloxymethyl-propane-1,3-diol

HRID 1459162노트

반응식

HRID 1459162 반응식
[CH2:1]([O:8][CH2:9][CH:10]1[CH2:15][O:14]C(C)(C)[O:12][CH2:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>CO>[CH2:1]([O:8][CH2:9][CH:10]([CH2:15][OH:14])[CH2:11][OH:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 232952655-((Benzyloxy)methyl)-2,2-dimethyl-1,3-dioxane

생성물 1

HCID 102417822-benzyloxymethyl-propane-1,3-diol수율 80%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 5-benzyloxymethyl-2,2-dimethyl-1,3-dioxane (3.40 g, 14.4 mmol) and a few crystals of p-toluenesulfonic acid monohydrate in 100 mL of methanol was stirred at room temperature for 20 h. The methanol was removed in vacuo and the residual oil purified by column chromatography on silica gel (ethyl acetate) to give 2.25 g (80%) of 2-benzyloxymethyl-1,3-propanediol as a colorless, clear liquid.

후처리

  1. customThe methanol was removed in vacuo
  2. customthe residual oil purified by column chromatography on silica gel (ethyl acetate)

출처 및 근거

ORD 기록
ord-a1b0a27d31e5423ca1d9533fd44f2c34
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05854228

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