2-Aminoisoquinoline → 2-Amino-5,6,7,8-tetrahydroisoquinoline acetate

HRID 1459261노트

반응식

HRID 1459261 반응식
[C:1]([OH:4])(=[O:3])[CH3:2].N=C1CC(C)CCN1.[NH2:13][N:14]1[CH:23]=[CH:22][C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:15]1>>[C:1]([OH:4])(=[O:3])[CH3:2].[NH2:13][N:14]1[CH:23]=[CH:22][C:21]2[CH2:20][CH2:19][CH2:18][CH2:17][C:16]=2[CH2:15]1

참가 물질

3

반응물 2

HCID 226396282-AminoisoquinolineHCID 1784758702-Imino-4-methylpiperidine acetate

생성물 1

HCID 184285932-Amino-5,6,7,8-tetrahydroisoquinoline acetate

실험 절차

The method of preparation of 2-imino-4-methylpiperidine acetate was used to convert 2-aminoisoquinoline to the title compound except platinum oxide was used as the catalyst. The product was triturated with EtOH to give a white solid. The analysis of the product was found to be consistent with the proposed structure. 1H NMR (D2O): δ7.35 (d, J=6 Hz, 1H); 6.55 (d, J=6 Hz, 1H); 2.6-2.5 (m, 2H); 2.20-2.10 (m, 2H); 1.75 (s, 3H); 1.70-1.50 (m, 4H).

출처 및 근거

ORD 기록
ord-bbebcdedacd04df88f0a571f2c50e010
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05854234

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