4-Chlorobenzylamine → Nicotinic acid, 2-(p-chlorobenzylamino)-

HRID 1459449노트

반응식

HRID 1459449 반응식
Cl[C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Cl:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16][NH2:17])=[CH:14][CH:13]=1>>[Cl:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16][NH:17][C:2]2[N:10]=[CH:9][CH:8]=[CH:7][C:3]=2[C:4]([OH:6])=[O:5])=[CH:14][CH:13]=1

참가 물질

3

반응물 2

HCID 660364-ChlorobenzylamineHCID 762582-Chloronicotinic acid

생성물 1

HCID 214597Nicotinic acid, 2-(p-chlorobenzylamino)-

반응 조건

온도
120 °C

실험 절차

A mixture of 2-chloronicotinic acid (30.0 g) and 4-chlorobenzylamine (45 ml) was heated at 120° C. for 3.5 hours. The mixture was cooled to ambient temperature and the solid obtained was washed with water and collected by filtration. The solid was boiled in methanol and filtered to give 2-(4-chlorobenzylamino)-nicotinic acid, m.p. 240°-242° C.

후처리

  1. temperatureThe mixture was cooled to ambient temperature
  2. customthe solid obtained
  3. washwas washed with water
  4. filtrationcollected by filtration
  5. filtrationfiltered

출처 및 근거

ORD 기록
ord-ec2ac6cea6f04b0d807284ac0a9c537e
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05854257

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