Paclitaxel → Taxane

HRID 1459662

반응식

HRID 1459662 반응식
C/C=C(/C(N[C@H]([C@@H](O)C(O[C@@H:19]1[C:40]([CH3:41])=[C:39]2[C:42]([CH3:44])([CH3:43])[C@:21](O)([C@@H:22](OC(C3C=CC=CC=3)=O)[C@@H:23]3[C@:28]4(OC(C)=O)[CH2:29]O[C@@H:27]4[CH2:26][C@H:25](O)[C@@:24]3([CH3:49])[C:36]([C@@H:38]2OC(C)=O)=O)[CH2:20]1)=O)C1C=CC=CC=1)=O)\C.CC1[C@@H](OC([C@H](O)[C@@H](NC(C2C=CC=CC=2)=O)C2C=CC=CC=2)=O)C[C@]2(O)C(C)(C)C=1[C@@H](OC(C)=O)C([C@@]1(C)[C@H]([C@@H]2OC(C2C=CC=CC=2)=O)[C@]2(OC(C)=O)CO[C@@H]2C[C@@H]1O)=O>>[CH3:29][C@H:28]1[C@H:23]2[CH2:22][C@H:21]3[C:42]([CH3:43])([CH3:44])[C@@H:39]([CH2:38][CH2:36][C@:24]2([CH3:49])[CH2:25][CH2:26][CH2:27]1)[C@H:40]([CH3:41])[CH2:19][CH2:20]3

참가 물질

3

반응물 2

HCID 36314PaclitaxelHCID 6436208Cephalomannine

생성물 1

HCID 9548828Taxane수율 20%

실험 절차

Batches of crude plant extracts from Taxus yunnanensis or from Taxus wallachiana containing approximately 15-40% cephalomannine, approximately 50-70% paclitaxel and approximately 20-35% other taxane/non-taxane components were obtained from the Peoples Republic of China. Chlorine gas was obtained from Matheson Ltd., and Silica gel used was ICN Silitech, 32-63 um, 60 Å, ICN Biomedicals, Inc., Aurora, Ohio. All solvents used were either HPLC or ACS grade and were obtained from Spectrum Chemical Mfg. Corp. Purified water used was deionized in-house.

출처 및 근거

ORD 기록
ord-7deae34fc59a49d78a8174efdae17edd
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05854278

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