Sodium Chloride → Propanamide, 2,2′-azobis[N-[2-[(2-hydroxyethyl)amino]ethyl]-2-methyl-

HRID 1459898노트

반응식

HRID 1459898 반응식
[N:1]([C:10]([CH3:16])([CH3:15])[C:11]([O:13]C)=O)=[N:2][C:3]([CH3:9])([CH3:8])[C:4]([O:6]C)=O.[NH2:17][CH2:18][CH2:19][NH:20][CH2:21][CH2:22][OH:23].[Cl-].[Na+]>CO>[N:2]([C:3]([CH3:8])([CH3:9])[C:4]([NH:17][CH2:18][CH2:19][NH:20][CH2:21][CH2:22][OH:23])=[O:6])=[N:1][C:10]([CH3:16])([CH3:15])[C:11]([NH:17][CH2:18][CH2:19][NH:20][CH2:21][CH2:22][OH:23])=[O:13]

참가 물질

5

반응물 3

HCID 5234Sodium ChlorideHCID 8112N-(2-Hydroxyethyl)ethylenediamineHCID 757631,1'-Dimethyl 2,2'-(1,2-diazenediyl)bis(2-methylpropanoate)

생성물 1

HCID 54254381Propanamide, 2,2′-azobis[N-[2-[(2-hydroxyethyl)amino]ethyl]-2-methyl-수율 80%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a constantly stirred mixture comprising 23.0 g of V-601, 22.9 g of 2-(2-aminoethylamino)ethanol and 5 ml of methanol, 4.7 g of 28% CH3 ONa was added dropwise. The reaction was carried out with stirring at room temperature for 8 hours. After standing overnight, the reaction mixture was mixed with 50 ml of saturated sodium chloride solution, and extracted with 100 ml of dichloromethane. The organic layer was dried over anhydrous magnesium sulfate and solvent was distilled off, and there was obtained 29.8 g (yield 80%) of 2,2'-azobis[N-(2-hydroxyethylamino)ethyl-2-methylpropionamide] of yellow viscous liquid.

후처리

  1. additionwas added dropwise
  2. waitAfter standing overnight
  3. extractionextracted with 100 ml of dichloromethane
  4. dry with materialThe organic layer was dried over anhydrous magnesium sulfate and solvent
  5. distillationwas distilled off

출처 및 근거

ORD 기록
ord-05d71fab04fc49be9451b1ee4d2d5401
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05854406

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