Imidazole → HCID 53792902, 화합물

HRID 1460046노트

반응식

HRID 1460046 반응식
Cl[C:2]1[N:7]=[C:6](Cl)[C:5]([N+:9]([O-:11])=[O:10])=[C:4]([CH:12]([CH3:14])[CH3:13])[N:3]=1.[NH:15]1[CH:19]=[CH:18][N:17]=[CH:16]1>C(#N)C>[N:15]1([C:2]2[N:7]=[C:6]([N:15]3[CH:19]=[CH:18][N:17]=[CH:16]3)[C:5]([N+:9]([O-:11])=[O:10])=[C:4]([CH:12]([CH3:14])[CH3:13])[N:3]=2)[CH:19]=[CH:18][N:17]=[CH:16]1

참가 물질

4

반응물 2

HCID 795ImidazoleHCID 214450712,4-Dichloro-5-nitro-6-(propan-2-yl)pyrimidine

생성물 1

HCID 53792902HCID 53792902, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Combine 29 g (0.12 mol) of 2,4-dichloro-5-nitro-6-(2-propyl)-pyrimidine with 42 g (0.62 mol) of imidazole in 500 mL of acetonitrile, and stir at room temperature for 24 h. Remove the solvent under vacuum, slurry the residue in 500 mL of CH2Cl2 and wash with 4×500 mL 10% K2CO3. Dry the organic portion over MgSO4, treat with charcoal, filter and concentrate the filtrate to dryness under vacuum to afford 2,4-bis(1H-imidazol-1-yl)-5-nitro-6-(2-propyl) pyrimidine.

후처리

  1. customRemove the solvent under vacuum
  2. washwash with 4×500 mL 10% K2CO3
  3. dry with materialDry the organic portion over MgSO4
  4. additiontreat with charcoal
  5. filtrationfilter
  6. concentrationconcentrate the filtrate to dryness under vacuum

출처 및 근거

ORD 기록
ord-9314b9fd52684adba8ce7a0cf51c75ce
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05854419

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