Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Fluorophenol → 4-(5-(tert-butyldimethylsilyloxy)-2-fluoro-alpha-hydroxybenzyl)-N,N-diethylbenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Fluorophenol | HCID 9707 | — |
| 반응물 | tert-Butyl(2-fluorophenoxy)dimethylsilane | HCID 597214 | — |
| 반응물 | N,N-diethyl-4-formylbenzamide | HCID 10954698 | — |
| 반응물 | CID 53628100 | HCID 178418400 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-(5-(tert-butyldimethylsilyloxy)-2-fluoro-alpha-hydroxybenzyl)-N,N-diethylbenzamide | HCID 54114191 | 34% |
반응 단계
tert-Butyldimethylsilyl 2-fluorophenyl ether (2.73 g, 12 mmol), prepared from 2-fluorophenol by the method in Example 1, was treated with sec-butyllithium (11 mL of 1.1M solution in cyclohexane) and 4-formyl-N,N-diethylbenzamide, (2.46 g, 12 mmol) from Example 11, by the procedure described in Example 29. Chromatography on silica gel with 1% methanol in dichloromethane gave 1.77 g (34%) of 4-(5-(tert-butyldimethylsilyloxy)-2-fluoro-α-hydroxybenzyl)-N,N-diethylbenzamide as a yellow oil that crystallized on standing.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05854249 |
| 출처 데이터셋 | uspto-grants-1998_12 |
| ORD ID | ord-b52f92addf7a435eb1ef7d93defd9f26 |
| 출처 메모 | uspto-grants-1998_12 |