Water → 4-[2-(3,4-Dichloro-phenoxy)-acetylamino]-thiophene-3-carboxylic acid methyl ester

참여 물질

역할	이름	HCID	투입량
반응물	Water	HCID 962	—
반응물	3,4-Dichlorophenol	HCID 7258	—
반응물	Potassium Carbonate	HCID 11430	—
반응물	3-Carbomethoxy-4-[(chloroacetyl)amino]thiophene	HCID 14510003	—
용매	Dimethylformamide	HCID 6228	—
생성물	4-[2-(3,4-Dichloro-phenoxy)-acetylamino]-thiophene-3-carboxylic acid methyl ester	HCID 68687458	70.1%

반응 조건

온도	90 °C

반응 단계

To a solution of methyl 4-(2-chloroacetamido)-3-thiophenecarboxylate ([51486-30-7], 100 mg, 0.428 mmol) in dimethylformamide (1.5 mL) was added potassium carbonate (88.7 mg, 0.642 mmol) and 3,4-dichlorophenol (83.7 mg, 0.514 mmol) and the reaction mixture was stirred at 90° C. overnight. After such time water was added. The precipitate was isolated by filtration, washed with water and dried in vacuo to yield the title compound as a white solid (108.1 mg, 70%).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07732452B2
출처 데이터셋	uspto-grants-2010_06
ORD ID	ord-a0fc8b04b02f43088383be8b4a8d9aae
출처 메모	uspto-grants-2010_06