Pyridine → HCID 15005407, 화합물
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Br[CH:2]([C:6]1[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[CH:8][CH:7]=1)[C:3](=O)[CH3:4].[C:14]([NH2:17])(=[S:16])[CH3:15].N1C=CC=CC=1>C1(C)C=CC=CC=1>[C:10]([C:9]1[CH:12]=[CH:13][C:6]([C:2]2[S:16][C:14]([CH3:15])=[N:17][C:3]=2[CH3:4])=[CH:7][CH:8]=1)#[N:11]참가 물질
5
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- 온도
- 100 °C
실험 절차
A solution of 4-(1-bromo-2-oxopropyl)benzonitrile (0.9 g, 3.83 mmol) in toluene (2 ml) was treated with thioacetamide (0.6 g, 8 mmol) followed by pyridine (0.45 ml). The mixture was warmed to 100° C. for 1 hour, then partitioned between ethyl acetate and brine. The organic layer was dried (MgSO4) and evaporated to a yellow oil. Chromatography on silica gel, eluting with 5% ether in dichloromethane, afforded a pale yellow oil which crystallised (0.52 g, 64%), m.p. 108°-110° C.
후처리
- custompartitioned between ethyl acetate and brine
- dry with materialThe organic layer was dried (MgSO4)
- customevaporated to a yellow oil
- washChromatography on silica gel, eluting with 5% ether in dichloromethane
- customafforded a pale yellow oil which
- customcrystallised (0.52 g, 64%), m.p. 108°-110° C.
출처 및 근거
- ORD 기록
- ord-ae3c1ff8ef7140debdf16a106c597579
- 출처 데이터셋
- uspto-grants-1991_12
- 특허 번호
- US05070205
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