2-Nitrophenyl isothiocyanate → Ethyl 3-[[[(2-nitrophenyl)amino]thioxomethyl]amino]-1-pyrrolidinecarboxylate

HRID 1460513노트

반응식

HRID 1460513 반응식
[NH2:1][CH:2]1[CH2:6][CH2:5][N:4]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH2:3]1.[N:12]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[N+:21]([O-:23])=[O:22])=[C:13]=[S:14]>O1CCCC1>[N+:21]([C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[NH:12][C:13]([NH:1][CH:2]1[CH2:6][CH2:5][N:4]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH2:3]1)=[S:14])([O-:23])=[O:22]

참가 물질

4

반응물 2

HCID 1376902-Nitrophenyl isothiocyanateHCID 13656208Ethyl 3-aminopyrrolidine-1-carboxylate

생성물 1

HCID 15037311Ethyl 3-[[[(2-nitrophenyl)amino]thioxomethyl]amino]-1-pyrrolidinecarboxylate수율 100%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 15.8 parts of ethyl 3-amino-1-pyrrolidinecarboxylate, 18 parts of 1-isothiocyanato-2-nitrobenzene and 180 parts of tetrahydrofuran was stirred for 1 hour at room temperature. The reaction mixture was evaporated, yielding 34 parts (100%) of ethyl 3[[[(2-nitrophenyl)amino]thioxomethyl]amino]-1-pyrrolidinecarboxylate as a residue (int. 22).

후처리

  1. customThe reaction mixture was evaporated

출처 및 근거

ORD 기록
ord-9817e4853a874b5a9a493268d3b2c7f7
출처 데이터셋
uspto-grants-1991_12
특허 번호
US05071846

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