Thiophene → ethyl 4-aminohexahydro-1H-azepine-1-carboxylate

HRID 1460518노트

반응식

HRID 1460518 반응식
C1(C[NH:8][CH:9]2[CH2:15][CH2:14][CH2:13][N:12]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:11][CH2:10]2)C=CC=CC=1.S1C=CC=C1.[H][H]>CO.[Pd]>[NH2:8][CH:9]1[CH2:15][CH2:14][CH2:13][N:12]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:11][CH2:10]1

참가 물질

6

반응물 3

HCID 8030ThiopheneHCID 15037322ethyl hexahydro-4-[(phenylmethyl)amino]-1H-azepine-1-carboxylateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 15037323ethyl 4-aminohexahydro-1H-azepine-1-carboxylate수율 100%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

69.1 Parts of ethyl hexahydro-4-[(phenylmethyl)amino]-1H-azepine-1-carboxylate were hydrogenated in the prescence of a solution of thiophene in methanol at normal pressure and at room temperature with 4 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated, yielding 46.9 parts (100%) of ethyl 4-aminohexahydro-1H-azepine-1-carboxylate as a residue (interm. 28).

후처리

  1. filtrationthe catalyst was filtered off
  2. customthe filtrate was evaporated

출처 및 근거

ORD 기록
ord-9f584e68a55b4e93952fd8aac5b2254b
출처 데이터셋
uspto-grants-1991_12
특허 번호
US05071846

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