HCID 136341208, 화합물 → 2-Amino-4-fluoro-6-methylphenol
반응식
[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]([OH:9])[C:4](C2C=CC=CC=2)([N:10]=NC2C=CC=CC=2O)[CH:3]=1>C(OCC)(=O)C.[Pd]>[NH2:10][C:4]1[CH:3]=[C:2]([F:1])[CH:7]=[C:6]([CH3:8])[C:5]=1[OH:9]참가 물질
4
실험 절차
A mixture of 5.75 g (25 mmoles) of 4-fluoro-6-methyl-2-phenylazophenol (B1) and 1.1 g of 5% Pd/c in ethyl acetate was shaken in a Parr shaker under hydrogen at room temperature for 17.5 hours. The reaction mixture was filtered through celite and the filtrate concentrated to an oil which was purified on silica gel eluting with hexane-ethyl acetate, giving 3.2 g of a white solid: m.p. 97° C. (dec).
후처리
- filtrationThe reaction mixture was filtered through celite
- concentrationthe filtrate concentrated to an oil which
- customwas purified on silica gel eluting with hexane-ethyl acetate
출처 및 근거
- ORD 기록
- ord-7705d81af164466f81711407ae904e9e
- 출처 데이터셋
- uspto-grants-1991_12
- 특허 번호
- US05071863
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