Chlorodifluoromethane → HCID 13961960, 화합물

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[Cl:1][C:2]1[CH:7]=[C:6]([OH:8])[N:5]=[C:4]([S:9][CH3:10])[N:3]=1.Cl[CH:12]([F:14])[F:13]>>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH:12]([F:14])[F:13])[N:5]=[C:4]([S:9][CH3:10])[N:3]=1

참가 물질

반응물 2

HCID 6372Chlorodifluoromethane

HCID 178503550HCID 178503550, 화합물

생성물 1

HCID 13961960HCID 13961960, 화합물

실험 절차

On the other hand, in the latter process, 4-chloro-6-hydroxy-2-methylthiopyrimidine as the starting material is first reacted with monochlorodifluoromethane to obtain 4-chloro-6-difluoromethoxy-2-methylthiopyrimidine, then this product was reacted with sodium nitrite in dimethylformamide t obtain 4-hydroxy-6-difluoromethoxy-2-methylthiopyrimidine, which is further reacted with monochlorodifluoromethane in dioxane in the presence of potassium hydroxide to obtain desired 4,6-bis(difluoromethoxy)-2-methylthiopyrimidine at a yield of 50%. However, this process also involves long process steps and is very cumbersome, and as such, it is not suitable as an industrial process.

출처 및 근거

ORD 기록: ord-6d835aa41cff4f3f8c5c4604176f94b2
출처 데이터셋: uspto-grants-1991_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05071982

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