2-(Benzylamino)acetic acid → Ethyl 1-benzylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate

HRID 1460749노트

반응식

HRID 1460749 반응식
[CH2:1]([N:4]([CH2:10][CH:11]=O)[C:5](=[O:9])[O:6][CH2:7][CH3:8])[CH:2]=[CH2:3].[CH2:13]([NH:20][CH2:21]C(O)=O)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C1(C)C=CC=CC=1>[CH2:13]([N:20]1[CH2:21][CH2:3][CH:2]2[CH:11]1[CH2:10][N:4]([C:5]([O:6][CH2:7][CH3:8])=[O:9])[CH2:1]2)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

4

반응물 2

HCID 869652-(Benzylamino)acetic acidHCID 11084330Ethyl allyl(2-oxoethyl)carbamate

생성물 1

HCID 11086974Ethyl 1-benzylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

42.8 g (0.25 mol) of ethyl N-allyl-N-(2-oxoethyl) -carbamate are heated under reflux overnight with 41.3 g (0.25 mol) of N-benzylglycine in 750 ml of toluene. The mixture is concentrated and the residue is distilled.

후처리

  1. concentrationThe mixture is concentrated
  2. distillationthe residue is distilled

출처 및 근거

ORD 기록
ord-ebc0674da76c498f8182c2ec2015f027
출처 데이터셋
uspto-grants-1991_12
특허 번호
US05071999

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