Barium Carbonate → Decahydropyrrolo[3,4-b]pyrrolizin-6-ol
반응식
[OH:1][CH:2]1[CH2:12][N:11]2[CH:4]([CH2:5][CH:6]3[CH:10]2[CH2:9][N:8](C(OCC)=O)[CH2:7]3)[CH2:3]1.C(=O)([O-])[O-].[K+].[K+].C(=O)([O-])[O-].[Ba+2]>O>[OH:1][CH:2]1[CH2:12][N:11]2[CH:4]([CH2:5][CH:6]3[CH:10]2[CH2:9][NH:8][CH2:7]3)[CH2:3]1참가 물질
5
실험 절차
8 g (33.3 mmol) of ethyl 10-hydroxy-1,4-diazatricyclo[6.3.0.02,6 ]undecane-4-carboxylate are heated under reflux overnight with 21 g of Ba(OH)2. 8H2O in 150 ml of water. The mixture is saturated with potassium carbonate, barium carbonate is filtered off with suction and the filtrate is extracted ten times using 100 ml of chloroform each time. The extracts are dried over potassium carbonate and concentrated, and the residue is distilled.
후처리
- filtrationis filtered off with suction
- extractionthe filtrate is extracted ten times
- dry with materialThe extracts are dried over potassium carbonate
- concentrationconcentrated
- distillationthe residue is distilled
출처 및 근거
- ORD 기록
- ord-7f889a169aba47fab081ad8be031cc4e
- 출처 데이터셋
- uspto-grants-1991_12
- 특허 번호
- US05071999
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