Chromic Acid → 4,4-Diphenylnon-8-en-3-one

HRID 1461149

반응식

HRID 1461149 반응식
[C:1]1([C:7]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)([CH2:12][CH2:13][CH2:14][CH:15]=[CH2:16])[CH:8]([OH:11])[CH2:9][CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cr](O)(O)(=O)=O>CC(C)=O>[C:17]1([C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)([CH2:12][CH2:13][CH2:14][CH:15]=[CH2:16])[C:8](=[O:11])[CH2:9][CH3:10])[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

참가 물질

4

반응물 2

HCID 24425Chromic AcidHCID 199815114,4-Diphenylnon-8-en-3-ol

생성물 1

HCID 199815084,4-Diphenylnon-8-en-3-one수율 78.8%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

One hundred seventy milligrams of 4,4-diphenylnon-8-en-3-ol was dissolved in acetone (10 ml), and then treated with 2.7M chromic acid solution (0.04 ml). After 10 min, the excess oxidant was destroyed with isopropanol, and the mixture was diluted with ether (20 ml). Filtration through a pad of celite and concentration yielded 133 mg of 4,4-diphenylnon-8-en-3-one, as an amorphous white solid.

후처리

  1. customthe excess oxidant was destroyed with isopropanol
  2. additionthe mixture was diluted with ether (20 ml)
  3. filtrationFiltration
  4. concentrationthrough a pad of celite and concentration

출처 및 근거

ORD 기록
ord-ed73cb74f4f64592b7d42a4b31c17767
출처 데이터셋
uspto-grants-1991_12
특허 번호
US05073629

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