4-Thiazolidinecarboxylic acid, methyl ester → Methyl 3-(((Ethoxy(propylthio)phosphinyl)amino)carbonyl)-4-thiazolidinecarboxylat

HRID 1461230

반응식

HRID 1461230 반응식
[S:1]1[CH2:5][CH:4]([C:6]([O:8][CH3:9])=[O:7])[NH:3][CH2:2]1.[P:10](=[O:21])([N:18]=[C:19]=[O:20])([S:14][CH2:15][CH2:16][CH3:17])[O:11][CH2:12][CH3:13]>CCOCC>[CH2:12]([O:11][P:10]([NH:18][C:19]([N:3]1[CH:4]([C:6]([O:8][CH3:9])=[O:7])[CH2:5][S:1][CH2:2]1)=[O:20])([S:14][CH2:15][CH2:16][CH3:17])=[O:21])[CH3:13]

참가 물질

4

반응물 2

HCID 933294-Thiazolidinecarboxylic acid, methyl esterHCID 19873995O-ethyl S-propyl phosphoroisocyanatidothioate

생성물 1

HCID 19980199Methyl 3-(((Ethoxy(propylthio)phosphinyl)amino)carbonyl)-4-thiazolidinecarboxylat

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To a solution of 2.2 g of methyl thiazolidine-4-carboxylate in 50 ml of ether was added dropwise with stirring at ambient temperature 3.14 g of O-ethyl S-propyl phosphoroisocyanatidothioate. The mixture was allowed to react overnight at ambient temperature and was then concentrated by evaporation under reduced pressure to obtain 5.2 (97 percent of theory) of the title compound as a colorless oil having a refractive index at 25° C. of 1.5312.

후처리

  1. customto react overnight at ambient temperature
  2. concentrationwas then concentrated by evaporation under reduced pressure

출처 및 근거

ORD 기록
ord-127e2becfb8343319dcb09eeeb9d3311
출처 데이터셋
uspto-grants-1991_12
특허 번호
US05075293

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