HCID 15675385, 화합물 → 1-(2-aminoethyl)-2,3-dihydro-2-oxo-1H-benzimidazole

HRID 1461270노트

반응식

HRID 1461270 반응식
[N:1]([CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[NH:8][C:7]1=[O:15])=[N+]=[N-].[H][H]>C(O)C.O.[C].[Pd]>[NH2:1][CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[NH:8][C:7]1=[O:15]

참가 물질

6

반응물 2

HCID 15675385HCID 15675385, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 117451761-(2-aminoethyl)-2,3-dihydro-2-oxo-1H-benzimidazole수율 89.1%

시약·촉매·용매 3

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매HCID 962Water용매

실험 절차

In 150 ml of ethanol was dissolved 1.3 g (6.4 mmol) of Compound i followed by addition of a suspension of 65 mg (5 w/w%) of 10% palladium-carbon in 2 ml of water. The mixture was stirred at room temperature for 4.5 hours, with hydrogen gas being bubbled into the mixture. The reaction mixture was then filtered and the filtrate was concentrated to give 1.01 g (89.1%) of 1-(2-aminoethyl)-2,3-dihydro-2-oxo-1H-benzimidazole (Compound j) as white crystals.

후처리

  1. custombeing bubbled into the mixture
  2. filtrationThe reaction mixture was then filtered
  3. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-74fff30f668c4f55893006e613832f27
출처 데이터셋
uspto-grants-1991_12
특허 번호
US05075301

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