Ammonium Hydroxide → HCID 178516142, 화합물

HRID 1461390노트

반응식

HRID 1461390 반응식
[F:1][C:2]([F:16])([F:15])[C:3](=O)[CH2:4][C:5](=[O:13])[CH2:6][C:7]([C:9]([F:12])([F:11])[F:10])=O.[OH-].[NH4+:18]>>[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[C:5]([OH:13])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[N:18]=1

참가 물질

3

반응물 2

HCID 14923Ammonium HydroxideHCID 115289171,1,1,7,7,7-Hexafluoroheptane-2,4,6-trione

생성물 1

HCID 178516142HCID 178516142, 화합물

반응 조건

온도
130 °C

실험 절차

A mixture of 30 g 1,5-di(trifluoromethyl)-1,3,5-trioxopentane and 125 ml 28% aqueous ammonium hydroxide was heated in an autoclave at 130° C. for 5 hours. The reaction mixture was concentrated in vacuo, dissolved in 350 ml ethanol and treated with 11 ml 6N hydrochloric acid. The resulting mixture was concentrated in vacuo, 100 ml water added to the residue and filtered to give 8.0 g 2,6-di(trifluoromethyl)-4-hydroxypyridine, m.p. 123°-130° C.

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. dissolutiondissolved in 350 ml ethanol
  3. additiontreated with 11 ml 6N hydrochloric acid
  4. concentrationThe resulting mixture was concentrated in vacuo, 100 ml water
  5. additionadded to the residue
  6. filtrationfiltered

출처 및 근거

ORD 기록
ord-2c61e2985da2400bb1878f8c245bf51c
출처 데이터셋
uspto-grants-1991_12
특허 번호
US05075319

반응 노트

불러오는 중…