Acetyl chloride → 2-(Acetyloxy)-4-(methylsulfanyl)butanoic acid

반응식

[OH:1][CH:2]([CH2:6][CH2:7][S:8][CH3:9])[C:3]([O-:5])=[O:4].[Ca+2].[OH:11][CH:12](CCSC)[C:13]([O-])=O.C(Cl)(=O)C>>[C:12]([O:1][CH:2]([CH2:6][CH2:7][S:8][CH3:9])[C:3]([OH:5])=[O:4])(=[O:11])[CH3:13]

참가 물질

반응물 2

HCID 6367Acetyl chloride

HCID 107344Calcium bis(2-hydroxy-4-(methylthio)butyrate)

생성물 1

HCID 30747282-(Acetyloxy)-4-(methylsulfanyl)butanoic acid수율 192.7%

실험 절차

Calcium 2-hydroxy-4-(methylthio)butyrate (33.8 g, 0.1 g-mole) and acetyl chloride (110 g) are refluxed in a 250 ml round-bottom flask for 2.5 hours. The mixture is evaporated to a syrup and treated with 150 ml acetone. The brown mixture is stirred for 30 minutes, filtered, and the filtrate evaporated to dryness to give 37 g, 96.4% of brown viscous oil which is identified by TLC and nmr.

후처리

customThe mixture is evaporated to a syrup
additiontreated with 150 ml acetone
filtrationfiltered
customthe filtrate evaporated to dryness

출처 및 근거

ORD 기록: ord-8174378126114fb7810c69dbc4a7ccd9
출처 데이터셋: uspto-grants-1991_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05075502

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