홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Potassium Hydroxide → 5-Chloro-2-[2-(6-chloro-2-pyridyl)propen-3-yl]-2-methylindan 1,3-dion

HRID 1461633
노트
인쇄 미리보기

반응식

HRID 1461633 반응식
[OH-].[K+].[Cl:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[CH:8]([CH3:14])[C:7]2=[O:15].[Cl:16][C:17]1[N:22]=[C:21]([C:23]([CH2:25]Cl)=[CH2:24])[CH:20]=[CH:19][CH:18]=1>CO.[I-].[K+]>[Cl:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[C:8]([CH2:25][C:23]([C:21]1[CH:20]=[CH:19][CH:18]=[C:17]([Cl:16])[N:22]=1)=[CH2:24])([CH3:14])[C:7]2=[O:15]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 14797Potassium HydroxideHCID 150087112-Chloro-6-(3-chloroprop-1-en-2-yl)pyridineHCID 539304495-Chloro-2-methylindan-1,3-dione

생성물 1

HCID 151168185-Chloro-2-[2-(6-chloro-2-pyridyl)propen-3-yl]-2-methylindan 1,3-dion수율 87%

시약·촉매·용매 2

HCID 4875Potassium Iodide촉매
HCID 887
Methanol
용매

실험 절차

In 20 ml of methanol was dissolved 1.32 g of 85% potassium hydroxide, and then 3.89 g of 5-chloro-2-methylindan-1,3-dione, 3.76 g of 6-chloro-2-(1-chloromethylvinyl)pyridine and 0.05 g of potassium iodide were added to the solution. After refluxing under heating for 3 hours, the solvent was evaporated and water was poured. The reaction mixture was extracted with ethyl acetate, the organic layer was washed with water and with a saturated saline solution, and then dried over anhydrous magnesium sulfate. After the solvent was evaporated, the residue was separated and purified by silica gel column chromatography (developing solvent: n-hexane/ethyl acetate=5/1) to obtain 6.02 g of the compound No. 115 shown in Table 1.

후처리

  1. temperatureAfter refluxing
  2. temperatureunder heating for 3 hours
  3. customthe solvent was evaporated
  4. additionwater was poured
  5. extractionThe reaction mixture was extracted with ethyl acetate
  6. washthe organic layer was washed with water and with a saturated saline solution
  7. dry with materialdried over anhydrous magnesium sulfate
  8. customAfter the solvent was evaporated
  9. customthe residue was separated
  10. custompurified by silica gel column chromatography (developing solvent: n-hexane/ethyl acetate=5/1)

출처 및 근거

ORD 기록
ord-ede28d899e7843c5873d4f5d0c3499ea
출처 데이터셋
uspto-grants-1991_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05076830

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트