1,1'-Carbonyldiimidazole → 11H-imidazo[1,2-c][1,3]benzodiazepin-5(6H)-one

HRID 1462174노트

반응식

HRID 1462174 반응식
[C:1]([N:8]1[CH:12]=[CH:11][N:10]=[CH:9]1)([N:3]1[CH:7]=[CH:6]N=C1)=[O:2].N[C:14]1[CH:25]=[CH:24]C=C[C:15]=1[CH2:16]C1NC=CN=1>C(Cl)Cl>[N:10]1[CH:11]=[CH:12][N:8]2[C:9]=1[CH2:24][C:25]1[CH:14]=[CH:15][CH:16]=[CH:6][C:7]=1[NH:3][C:1]2=[O:2]

참가 물질

4

반응물 2

HCID 682631,1'-CarbonyldiimidazoleHCID 133449032-[(1H-Imidazol-2-yl)methyl]aniline

생성물 1

HCID 1334492211H-imidazo[1,2-c][1,3]benzodiazepin-5(6H)-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Alternately, 0.75 g of 1,1'-carbonyldiimidazole was added at once to a suspension of 0.79 g of 2-(2-aminobenzyl)imidazole in 38 ml of methylene chloride and the mixture was stirred at room temperature overnight. The resulting precipitate was collected and recrystallized from methylene chloride to give the crude 11H-imidazo[1,2-c][1,3]benzodiazepin-5(6H)-one, m.p. 238°-40°.

후처리

  1. customThe resulting precipitate was collected
  2. customrecrystallized from methylene chloride

출처 및 근거

ORD 기록
ord-9a4d0c97835c4a678cefab9d864f58e9
출처 데이터셋
uspto-grants-1984_07
특허 번호
US04459232

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