Pyridine → 2,3-Dicyano-5-chloro-6-ethylthiopyrazine

HRID 1462305

반응식

HRID 1462305 반응식
[C:1]([C:3]1[C:8]([C:9]#[N:10])=[N:7][C:6](Cl)=[C:5]([Cl:12])[N:4]=1)#[N:2].[CH2:13]([SH:15])[CH3:14].N1C=CC=CC=1>CC(C)=O.O>[C:9]([C:8]1[C:3]([C:1]#[N:2])=[N:4][C:5]([Cl:12])=[C:6]([S:15][CH2:13][CH3:14])[N:7]=1)#[N:10]

참가 물질

6

반응물 3

HCID 1049PyridineHCID 6343EthanethiolHCID 6078205,6-Dichloro-2,3-dicyanopyrazine

생성물 1

HCID 128737542,3-Dicyano-5-chloro-6-ethylthiopyrazine수율 29.4%

시약·촉매·용매 2

HCID 180Acetone용매HCID 962Water용매

실험 절차

2,3-Dicyano-5,6-dichloropyrazine (1.00 g; 0.005 mole) and 0.47 g of ethanethiol were dissolved in 50 ml of acetone. The solution was cooled to -15° to -10° C., and a solution of 0.40 g (0.005 mole) of pyridine in 40 ml of water was added dropwise over the period of 30 minutes. The mixture was worked up in the same way as in Example 26 to afford 0.33 g (yield 29%) of 2,3-dicyano-5-chloro-6-ethylthiopyrazine.

후처리

  1. temperatureThe solution was cooled to -15° to -10° C.

출처 및 근거

ORD 기록
ord-e45b35f256e542e4923d2ef801e67df9
출처 데이터셋
uspto-grants-1984_07
특허 번호
US04460403

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