4-Chlorobenzoyl chloride → N-(4-chlorobenzoyl)-N-[(2-thienylcarbonyl)methyl]amine

HRID 1462426노트

반응식

HRID 1462426 반응식
Cl.[S:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]([CH2:9][NH2:10])=[O:8].C(=O)(O)[O-].[Na+].[Cl:16][C:17]1[CH:25]=[CH:24][C:20]([C:21](Cl)=[O:22])=[CH:19][CH:18]=1>>[Cl:16][C:17]1[CH:25]=[CH:24][C:20]([C:21]([NH:10][CH2:9][C:7]([C:3]2[S:2][CH:6]=[CH:5][CH:4]=2)=[O:8])=[O:22])=[CH:19][CH:18]=1

참가 물질

4

반응물 3

HCID 85014-Chlorobenzoyl chlorideHCID 516892Sodium BicarbonateHCID 126098332-Amino-1-(thiophen-2-yl)ethan-1-one hydrochloride

생성물 1

HCID 13105423N-(4-chlorobenzoyl)-N-[(2-thienylcarbonyl)methyl]amine수율 99.5%

실험 절차

5.0 g of N-[(2-thienylcarbonyl)methyl]amine hydrochloride, 10.0 g of sodium bicarbonate and 4.78 g of 4-chlorobenzoyl chloride are treated in the same manner as described in Preparation 1-(3). 7.6 g of N-(4-chlorobenzoyl)-N-[(2-thienylcarbonyl)methyl]amine are thereby obtained.

후처리

  1. customas described in Preparation 1-(3)

출처 및 근거

ORD 기록
ord-a2eb3f821adf42b497db155ae0a20373
출처 데이터셋
uspto-grants-1984_07
특허 번호
US04460596

반응 노트

불러오는 중…