1,1'-Carbonyldiimidazole → 11H-imidazo[1,2-c][1,3]benzodiazepin-5(6H)-one

HRID 1462441노트

반응식

HRID 1462441 반응식
[C:1]([N:8]1[CH:12]=[CH:11][N:10]=[CH:9]1)([N:3]1[CH:7]=[CH:6]N=C1)=[O:2].N[C:14]1[CH:25]=[CH:24]C=C[C:15]=1[CH2:16]C1NC=CN=1>C(Cl)Cl>[N:10]1[CH:11]=[CH:12][N:8]2[C:9]=1[CH2:24][C:25]1[CH:14]=[CH:15][CH:16]=[CH:6][C:7]=1[NH:3][C:1]2=[O:2]

참가 물질

4

반응물 2

HCID 682631,1'-CarbonyldiimidazoleHCID 133449032-[(1H-Imidazol-2-yl)methyl]aniline

생성물 1

HCID 1334492211H-imidazo[1,2-c][1,3]benzodiazepin-5(6H)-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Alternately, 0.75 g of 1,1'-carbonyldiimidazole is added at once to a suspension of 0.79 g of 2-(2-aminobenzyl)imidazole in 38 ml of methylene chloride and the mixture is stirred at room temperature overnight. The resulting precipitate is collected and recrystallized from methylene chloride to give the crude 11H-imidazo[1,2-c][1,3]benzodiazepin-5(6H)-one, m.p. 238°-40°.

후처리

  1. customThe resulting precipitate is collected
  2. customrecrystallized from methylene chloride

출처 및 근거

ORD 기록
ord-0bd503accad743658d621b2f23b73232
출처 데이터셋
uspto-grants-1984_07
특허 번호
US04460587

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