Sodium Iodide → HCID 178472996, 화합물

HRID 1462927

반응식

HRID 1462927 반응식
[CH2:1]([O:3][C:4]([N:6]1[CH:10]=[CH:9][N:8]=[CH:7]1)=[O:5])[CH3:2].Cl[CH2:12][C:13]1[CH:25]=[CH:24][C:16]([O:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:15][CH:14]=1.[I-:26].[Na+]>C(#N)C>[I-:26].[CH2:1]([O:3][C:4]([N+:6]1[CH:10]=[CH:9][N:8]([CH2:12][C:13]2[CH:14]=[CH:15][C:16]([O:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:24][CH:25]=2)[CH:7]=1)=[O:5])[CH3:2]

참가 물질

5

반응물 3

HCID 5238Sodium IodideHCID 87963Ethyl 1H-imidazole-1-carboxylateHCID 4351015(4-Chloromethyl-phenoxy)-acetic acid ethyl ester

생성물 1

HCID 178472996HCID 178472996, 화합물수율 100%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

1.4 g of 1-ethoxycarbonylimidazole, 2.5 g of ethyl 4-chloromethylphenoxyacetate and 1.7 g of sodium iodide were added to 5 ml of dry acetonitrile, and the mixture was stirred at room temperature for 6 hours. After completion of the reaction, the insoluble materials were filtered off and the filtrate was concentrated under reduced pressure. The residue was triturated with an adequate amount of dry diethyl ether, the resulting powder was collected by filtration and dried to obtain 4.6 g of 1-ethoxycarbonyl-3-(4-ethoxycarbonylmethoxybenzyl)imidazolium iodide (quantitative yield). Colorless hygroscopic amorphous.

후처리

  1. customAfter completion of the reaction
  2. filtrationthe insoluble materials were filtered off
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customThe residue was triturated with an adequate amount of dry diethyl ether
  5. filtrationthe resulting powder was collected by filtration
  6. customdried

출처 및 근거

ORD 기록
ord-f155f51ea6a94ecc9499bbd71347b6f3
출처 데이터셋
uspto-grants-1984_07
특허 번호
US04461905

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