Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phosphoric Acid → (+/-)-2-p-Tolylchroman-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phosphoric Acid | HCID 1004 | — |
| 반응물 | 1-(2-Hydroxyphenyl)-3-(4-methylphenyl)prop-2-en-1-one | HCID 617249 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | 2-Methoxyethanol | HCID 8019 | — |
| 생성물 | (+/-)-2-p-Tolylchroman-4-one | HCID 2802466 | — |
반응 단계
The 2'-Hydroxy-4-methylchalcone of Example 13 (7.3 g.) was boiled under reflux with a solution of 85% phosphoric acid (22 ml.) in 2-methoxyethanol (219 ml.) for 8 hrs. The reaction mixture was diluted with water (1 liter) and the oily precipitate extracted into dichloromethane (300 ml.). The organic extract was separated and washed with water and saturated sodium bicarbonate solution. Filtration and evaporation gave a residue of 4'-methylflavanone contaminated with the starting chalcone.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04461907 |
| 출처 데이터셋 | uspto-grants-1984_07 |
| ORD ID | ord-384e663e01314cf0b77e10d0f218e8a6 |
| 출처 메모 | uspto-grants-1984_07 |