Dichloromethane → Acetyl chloride

반응식

[C:1]([O:4]CC1CS[C@@H]2C(N[C:31]3[NH:32][C:33]4[C:39]([NH:40]C(=O)C)=[CH:38][CH:37]=[CH:36][C:34]=4[N:35]=3)C(=O)N2C=1C(OC(C1C=CC=CC=1)C1C=CC=CC=1)=O)(=O)[CH3:2].C(Cl)[Cl:46]>>[NH2:40][C:39]1[C:33]2[NH:32][CH:31]=[N:35][C:34]=2[CH:36]=[CH:37][CH:38]=1.[C:1]([Cl:46])(=[O:4])[CH3:2]

참가 물질

반응물 2

HCID 6344Dichloromethane

HCID 178474104HCID 178474104, 화합물

생성물 2

HCID 6367Acetyl chloride

HCID 178507452HCID 178507452, 화합물

실험 절차

The diphenylmethyl 3-acetoxymethyl-7-(4-acetylaminobenzimidazol-2-yl)aminoceph-3-em-4-carboxylate used as starting material may be obtained by reaction of the corresponding 4-aminobenzimidazole derivative in dry methylene chloride with excess acetyl chloride and purifying the product by chromatography on silica using CH2Cl2 /MeOH/HOAc 97:1:2 v/v/v as eluant.

출처 및 근거

ORD 기록: ord-cb83181cc70e410ab830f3ef2957f50d
출처 데이터셋: uspto-grants-1984_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04463173

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