O-Methyltyramine → HCID 18982108, 화합물

HRID 1463269노트

반응식

HRID 1463269 반응식
[NH2:1][C:2]1[C:7]([N:8]=[O:9])=[C:6]([NH2:10])[N:5]=[C:4](SC)[N:3]=1.[CH3:13][O:14][C:15]1[CH:23]=[CH:22][C:18]([CH2:19][CH2:20][NH2:21])=[CH:17][CH:16]=1>O>[NH2:1][C:2]1[C:7]([N:8]=[O:9])=[C:6]([NH2:10])[N:5]=[C:4]([NH:21][CH2:20][CH2:19][C:18]2[CH:22]=[CH:23][C:15]([O:14][CH3:13])=[CH:16][CH:17]=2)[N:3]=1

참가 물질

4

반응물 2

HCID 4657O-MethyltyramineHCID 3276844,6-Pyrimidinediamine, 2-(methylthio)-5-nitroso-

생성물 1

HCID 18982108HCID 18982108, 화합물수율 84%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 4,6-diamino-2-methylthio-5-nitrosopyrimidine (10 g, 5.4 mM), 4-methoxyphenethylamine (7.92 ml, 5.4 mM) and water (180 ml) was heated to reflux for one hour. After cooling the red solid was separated by filtration, washed with water, and dried. There was thus obtained 4,6-diamino-2-[2-(4-methoxyphenyl)ethyl]amino-5-nitrosopyrimidine (13.4 g, 84% yield). NMR: DMSO-d6 ; 2.7-2.85(m,2H, CH2 --CH2), 3.4-3.6(m, 2H, CH2 --NH), 3.7 (s, 3H, OCH3), 6.75-6.8(m,2H, aromatic-H), 7.05-7.25 (m, 2H, aromatic-H), 7.4-10.5 (m, 5H, NH2 ×2, NH), m/e [M+H[+ 289.

후처리

  1. temperaturewas heated
  2. temperatureto reflux for one hour
  3. temperatureAfter cooling the red solid
  4. customwas separated by filtration
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-ef8c6785a21945508157d766f6bbd8a3
출처 데이터셋
uspto-grants-1994_04
특허 번호
US05300509

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