Sodium Cyanide → 114812-34-9

HRID 1463516노트

반응식

HRID 1463516 반응식
Cl.[CH2:2]([N:4]1[CH2:8][CH2:7][CH2:6][C@H:5]1[C:9]([O:11]C)=O)[CH3:3].[C-]#[N:14].[Na+]>N.CO>[CH2:2]([N:4]1[CH2:8][CH2:7][CH2:6][C@H:5]1[C:9]([NH2:14])=[O:11])[CH3:3]

참가 물질

5

반응물 2

HCID 8929Sodium CyanideHCID 86747729methyl (S)-1-ethyl-2-pyrrolidinecarboxylate hydrochloride

생성물 1

HCID 10866443114812-34-9수율 632.9%

시약·촉매·용매 2

HCID 222Ammonia용매HCID 887Methanol용매

실험 절차

Crude methyl (S)-1-ethyl-2-pyrrolidinecarboxylate hydrochloride (2.1 g, 0.01 mol; Example 6A) and NaCN (50 mg, 0.001 mol) in 30 ml 9M NH3 in MeOH was heated to 45° C. in a sealed glass flask for 2 days. GLC showed a conversion of 95% and usual work-up afforded 0.9 g (63%) of the title compound.

출처 및 근거

ORD 기록
ord-4b36c8c9c2f3439797ae430952b93e34
출처 데이터셋
uspto-grants-1994_04
특허 번호
US05300660

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