Propiolic Acid → cis-3-(Acetylthio)propenoic acid
반응식
[C:1]([OH:5])(=[O:4])[C:2]#[CH:3].[C:6]([OH:9])(=[S:8])[CH3:7]>C(O)C.C(N(CC)CC)C>[C:6]([S:8]/[CH:3]=[CH:2]\[C:1]([OH:5])=[O:4])(=[O:9])[CH3:7]참가 물질
5
실험 절차
To a stirred, cooled (0° C.) solution of 1.0 ml (0.01625 mol) of propiolic acid in 12 ml of absolute ethanol under nitrogen was added 0.22 ml (0.0016 mol) of triethylamine. After 5 min, 1.45 ml (0.0203 mol) of thioacetic acid was added. After 20 h at 0° C. the reaction mixture was stripped of solvents to give 2.8 g of cis-3-(acetylthio)propenoic acid as a waxy solid. This product was used in the next step without further purification.
후처리
- waitAfter 20 h at 0° C. the reaction mixture was stripped of solvents
출처 및 근거
- ORD 기록
- ord-1de88a56f16c4a698135c130a525df1c
- 출처 데이터셋
- uspto-grants-1994_04
- 특허 번호
- US05300672
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