HCID 19380545, 화합물 → HCID 178513639, 화합물

HRID 1463741노트

반응식

HRID 1463741 반응식
[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[CH2:6][CH:7]=[C:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:22]=[CH:21][C:17]([C:18]([NH2:20])=[O:19])=[CH:16][CH:15]=2)[CH2:10][CH2:9]1>[Pt].C.O1CCOCC1.C(N(CC)CC)C>[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[CH2:6][CH2:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([C:14]2[CH:15]=[CH:16][C:17]([C:18]([NH2:20])=[O:19])=[CH:21][CH:22]=2)[CH2:10][CH2:9]1

참가 물질

4

반응물 1

HCID 19380545HCID 19380545, 화합물

생성물 1

HCID 178513639HCID 178513639, 화합물수율 45.7%

시약·촉매·용매 2

HCID 16218561HCID 16218561, 화합물촉매HCID 68453242Dioxan triethylamine용매

실험 절차

A mixture of 500 mg of 4-[4-[2-(1,3-dioxolan-2-yl)-ethylidene]cyclohexyl]benzamide and 20 ml of dioxan/triethylamine (vol. 9:1) was hydrogenated by means of 500 mg of 10 percent platinum-charcoal for 2 hours. The reaction mixture was then filtered and the filtrate was evaporated. Recrystallization of the evaporation residue from 40 ml of dioxan gave 230 mg of 4-[trans-4-[2-(1,3-dioxolan-2-yl) ethyl]cyclohexyl]benzamide as colorless crystals.

후처리

  1. filtrationThe reaction mixture was then filtered
  2. customthe filtrate was evaporated
  3. customRecrystallization of the evaporation residue from 40 ml of dioxan

출처 및 근거

ORD 기록
ord-a2afbbc522aa45c18d5482667a6315f6
출처 데이터셋
uspto-grants-1994_04
특허 번호
US05302317

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