HCID 22851231, 화합물 → HCID 22851233, 화합물

HRID 1463784노트

반응식

HRID 1463784 반응식
C([O:8][CH2:9][C@@H:10]([O:12][CH2:13][P:14]([O:20][CH:21]([CH3:23])[CH3:22])([O:16][CH:17]([CH3:19])[CH3:18])=[O:15])[CH3:11])C1C=CC=CC=1>[OH-].[OH-].[Pd+2].C(O)C.C1CCCCC=1>[CH:21]([O:20][P:14]([CH2:13][O:12][C@@H:10]([CH3:11])[CH2:9][OH:8])([O:16][CH:17]([CH3:18])[CH3:19])=[O:15])([CH3:22])[CH3:23]

참가 물질

4

반응물 1

HCID 22851231HCID 22851231, 화합물

생성물 1

HCID 22851233HCID 22851233, 화합물수율 104.1%

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 18676862Cyclohexene ethanol용매

실험 절차

A solution of (S)-1-O-benzyl-2-O-[(diisopropylphosphono)methyl]-1,2-propanediol (8.20 g, 23.8 mmol) in 1:1 ethanol/cyclohexene (80 mL) was treated with 20% palladium hydroxide on carbon (4.0 g), and the mixture was heated at reflux for 18 hours. The reaction mixture was then filtered through a 1" pad of Celite, and the filtrate was concentrated in vacuo to give 6.3 g of the title compound as a clear, colorless oil which was used in the following reaction without purification.

후처리

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 18 hours
  3. filtrationThe reaction mixture was then filtered through a 1" pad of Celite
  4. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-7f46e3e48c5c4caabe937a351adb4096
출처 데이터셋
uspto-grants-1994_04
특허 번호
US05302585

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