3,5-Dimethylaniline → 3,5-diMethyl-cyclohexylaMine

HRID 1463835노트

반응식

HRID 1463835 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([CH3:9])[CH:8]=1)[NH2:5]>[Ru]>[CH3:1][CH:2]1[CH2:8][CH:7]([CH3:9])[CH2:6][CH:4]([NH2:5])[CH2:3]1

참가 물질

3

반응물 1

HCID 79493,5-Dimethylaniline

생성물 1

HCID 146753743,5-diMethyl-cyclohexylaMine

시약·촉매·용매 1

HCID 23950Ruthenium촉매

실험 절차

N-cis, cis-3,5-Dimethylcyclohexyl-N-cyclopentyl amine is synthesized as shown in Scheme M. 3,5-Dimethylcyclohexyl amine is synthesized by catalytic hydrogenation of 3,5-dimethyl aniline for 7 to 24 hours. A suitable catalyst is 5% ruthenium on carbon. Hydrogenation pressure may change from 500 to 1500 psi and temperatures may range from 80° to 150°. N-cis cis-3,5-Dimethylcyclohexyl-N-cyclopentyl amine is formed by reductive amination of cyclpentanone with 3,5-dimethylcyclohexyl amine. The reductive amination may be carried out by hydrogenation using palladium on carbon as catalyst at pressures ranging from 15 to 90 psi. The temperature may range from room temperature to 50°. The reaction time is from 7 to 48 hours.

후처리

  1. customN-cis, cis-3,5-Dimethylcyclohexyl-N-cyclopentyl amine is synthesized
  2. custommay range from 80° to 150°

출처 및 근거

ORD 기록
ord-5c3fca26dacd4245867dc83c1a5f047a
출처 데이터셋
uspto-grants-1994_04
특허 번호
US05302601

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