Ethyl Acetate → HCID 19089105, 화합물
반응식
[CH2:1]([O:3][CH:4]([O:8][CH2:9][CH3:10])[CH2:5][NH:6][NH2:7])[CH3:2].CO[C:13](=[CH2:16])[C:14]#[N:15].C(OCC)(=O)C>O>[CH2:1]([O:3][CH:4]([O:8][CH2:9][CH3:10])[CH2:5][N:6]1[C:14]([NH2:15])=[CH:13][CH:16]=[N:7]1)[CH3:2]참가 물질
5
실험 절차
A mixture of hydrazinoacetaldehyde diethyl acetal (21 g) and methoxyacrylonitrile (11.8 g) in water (150 ml) was refluxed for 2 days. After the reaction mixture was cooled, to the mixture was added a mixture of water and ethyl acetate. The separated organic layer was washed with brine and dried over magnesium sulfate. The solvent was evaporated and the residue was subjected to column chromatography on silica gel using ethyl acetate as an eluent. Fractions containing the object compound were combined and evaporated to give 1-(2,2-diethoxyethyl)-5-aminopyrazole (5.45 g).
후처리
- temperaturewas refluxed for 2 days
- temperatureAfter the reaction mixture was cooled, to the mixture
- additionwas added
- washThe separated organic layer was washed with brine
- dry with materialdried over magnesium sulfate
- customThe solvent was evaporated
- additionFractions containing the object compound
- customevaporated
출처 및 근거
- ORD 기록
- ord-18a4391a669a48c38274b7f29de18659
- 출처 데이터셋
- uspto-grants-1994_04
- 특허 번호
- US05302712
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