N-Methylethylenediamine → HCID 178480592, 화합물

HRID 1464035노트

반응식

HRID 1464035 반응식
I.[C:2]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=N)SC.[CH3:19][NH:20][CH2:21][CH2:22][NH2:23].[C:24]([OH:31])(=[O:30])/[CH:25]=[CH:26]/[C:27]([OH:29])=[O:28]>C(O)C.CO>[C:24]([OH:31])(=[O:30])/[CH:25]=[CH:26]/[C:27]([OH:29])=[O:28].[CH3:19][N:20]1[CH2:21][CH2:22][NH:23][C:9]1=[N:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

6

반응물 3

HCID 8014N-MethylethylenediamineHCID 444972Fumaric AcidHCID 178503972HCID 178503972, 화합물

생성물 1

HCID 178480592HCID 178480592, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 887Methanol용매

실험 절차

A mixture of 1-(2-biphenylyl)-2-methyl-2-thiopseudourea hydriodide (5.6 g) and N-methylethylenediamine (3.3 g) in ethanol (70 ml) was heated under reflux for 48 hours. Removal of the solvent gave an oil which was dissolved in methanol (25 ml) and treated with fumaric acid (1.7 g) to give 2-(1-methyl-2-imidazolidinylideneamino)biphenyl fumarate (m.p. 168°-169° C.) which was recrystallised from a 1:1 mixture of methanol and ether.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 48 hours
  3. customRemoval of the solvent
  4. customgave an oil which

출처 및 근거

ORD 기록
ord-eac13c1931e74b5b968f4925da3563c3
출처 데이터셋
uspto-grants-1994_04
특허 번호
US05302720

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