Ethanol → 2-[1-(2-Hydroxyethyl)-2-imidazolidinyl-idene]-aminobiphenyl fumarate

HRID 1464036노트

반응식

HRID 1464036 반응식
I.[C:2]1([C:13]2C=CC=CC=2)[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8]C(=N)SC.[OH:19][CH2:20][CH2:21][NH:22][CH2:23][CH2:24][NH2:25].[C:26]([OH:33])(=[O:32])/[CH:27]=[CH:28]/[C:29]([OH:31])=[O:30].[CH2:34](O)[CH3:35]>CO>[C:26]([OH:33])(=[O:32])/[CH:27]=[CH:28]/[C:29]([OH:31])=[O:30].[OH:19][CH2:20][CH2:21][N:22]1[CH2:23][CH2:24][NH:25][C:13]1=[C:2]1[CH:3]([NH2:8])[CH:4]=[CH:5][CH:6]=[C:7]1[C:35]1[CH:34]=[CH:29][CH:28]=[CH:27][CH:26]=1

참가 물질

6

반응물 4

HCID 702EthanolHCID 8112N-(2-Hydroxyethyl)ethylenediamineHCID 444972Fumaric AcidHCID 178503972HCID 178503972, 화합물

생성물 1

HCID 1317183872-[1-(2-Hydroxyethyl)-2-imidazolidinyl-idene]-aminobiphenyl fumarate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 1-(2-biphenylyl)-2-methyl-2-thiopseudourea hydriodide (12 g prepared as described in Example 5) and N-(2-hydroxyethyl)ethylenediamine (10 g) in ethanol (145 ml) was heated under reflux for 165 hours. Removal of the solvent gave an oil which was dissolved in methanol and treated with fumaric acid to give 2-[1-(2-hydroxyethyl)-2-imidazolidinyl-idene]-aminobiphenyl fumarate (m.p. 165°-166° C.) which was recrystallised from a 1:2 mixture of methanol and ether.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 165 hours
  3. customRemoval of the solvent
  4. customgave an oil which

출처 및 근거

ORD 기록
ord-7676d414f45440c9b06f6714e0dd189a
출처 데이터셋
uspto-grants-1994_04
특허 번호
US05302720

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